Barcelona SC vs Boca Juniors

With Barcelona SC stranded at the foot of Group D — zero points and a brutal -5 goal difference — this is a must-win in the truest sense. Boca Juniors, sitting comfortably in second on six points, have already dismantled their hosts 3-0 in Buenos Aires earlier in the group phase. Barcelona arrive off a flat 1-1 Liga Pro draw with Manta FC, their slim hopes resting on Byron Castillo, Jefferson Intriago, and forward Klever Caicedo. Boca, meanwhile, head into this trip with a crowded medical room: Edinson Cavani, Ander Herrera, Agustín Marchesín, and Rodrigo Battaglia are all sidelined. Milton Giménez is set to spearhead the Argentine attack. Even depleted, Boca coach Claudio Úbeda has spoken confidently ahead of the trip to Guayaquil — and the head-to-head record backs him up. Barcelona SC will need to push forward and leave gaps, which suits the visitors perfectly. Our prediction: 1-2