Boston River host River Plate at Campeones Olímpicos in Florida in the Copa AUF Uruguay last 16, a one-off knockout tie with no second leg to fall back on. The home side come in after a 3-2 win over Fénix in group 6 that put them through. Luca Babino opened that game after ten minutes with a left-footed shot from distance. Over their last five matches Boston River have won three and lost two, both of those defeats by 1-0, to Defensor Sporting and Racing. They also won 1-0 at Liverpool. There was little to be found on the recent form of River Plate. History leans towards the hosts. Boston River won 2-0 in the league in September 2025, and before that meeting they led the series with 10 wins to 7, with 7 draws. Bookmakers have them at 1.90 to win, against 3.85 for River Plate. Our prediction: 2-1